منابع مشابه
Membrane Immunoglobulins of B Lymphocytes
Hemagglutination and fluorescent antibody studies have provided strong evidence for the unavailability or absence of specific antigenic sites on membrane-bound IgM which are present in serum and intracellular IgM. Antisera specific for different parts of the molecule indicated that a portion but not all of the Fc was involved. Absorption experiments with normal and leukemic viable B lymphocytes...
متن کاملImmunoglobulins on the Surface of Lymphocytes
Immunofluorescent studies using live cells from antibody-forming organs and anti-immunoglobulin antibodies demonstrate two populations of small lymphocytes which are differentiated by the presence or absence of Ig on their surface membranes. Most of the lymphocytes with detectable surface Ig appear to derive from cells of the bone marrow, while most of the Ig-negative lymphocytes derive from th...
متن کاملIntravenous immunoglobulins induce the in vitro differentiation of human B lymphocytes and the secretion of IgG.
The therapeutic effects of intravenous immunoglobulins (IVIGs) in several autoimmune diseases are characterized by a decrease in pathologic autoantibody levels. Although little direct evidence has been reported in humans, the large repertoire of natural immunoglobulin G (IgG) antibodies in IVIGs is expected to be involved in the regulation of autoreactive B lymphocytes. In normal adult mice, IV...
متن کاملTumor-infiltrating B lymphocytes as an efficient source of highly specific immunoglobulins recognizing tumor cells
BACKGROUND There is much evidence that tumor cells elicit a humoral immune response in patients. In most cases, the presence of antibodies in peripheral blood is detected only in small proportion of patients with tumors overexpressing the corresponding antigen. In the present study, we analyzed the significance of local humoral response provided by tumor-infiltrating lymphocytes in breast cance...
متن کاملLeukemic - Like Membrane Properties Acquired by B Lymphocytes
Human peripheral blood lymphocytes can be phenotypically identified by the presence of one or both of two proteins. 225,000-dalton macromolecular insoluble cold globulin (225-MICG) and 185,000-dalton MICG (185-MICG). T cells synthesize and insert into their plasma membrane 225MICG. null cells 1 85-MICG. and B cells both 225 and 1 85-MICG. In contrast, the monoclonal B cells of chronic lymphocyt...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1974
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.140.4.895